InnateDB Protein
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IDBP-201439.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Epcam
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Protein Name
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epithelial cell adhesion molecule
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Synonyms
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CD326; EGP; EGP-2; Egp314; Ep-CAM; EpCAM1; GA733-2; gp40; Ly74; Tacsd1; Tacstd1; TROP1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000061935
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InnateDB Gene
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IDBG-201437 (Epcam)
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Protein Structure
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Function |
May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E (By similarity). {ECO:0000250}.
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Subcellular Localization |
Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Lateral cell membrane {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Note=Colocalizes with CLDN7 at the lateral cell membrane and tight junction. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
GO:0001657
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ureteric bud development
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GO:0008284
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positive regulation of cell proliferation
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GO:0023019
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signal transduction involved in regulation of gene expression
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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GO:0048863
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stem cell differentiation
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GO:2000048
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negative regulation of cell-cell adhesion mediated by cadherin
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GO:2000648
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positive regulation of stem cell proliferation
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Cellular Component |
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PDB ID |
MGI:106653
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InterPro |
IPR000716
Thyroglobulin type-1
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PFAM |
PF00086
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PRINTS |
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PIRSF |
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SMART |
SM00211
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TIGRFAMs |
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Modification |
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SwissProt |
Q99JW5
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PhosphoSite |
PhosphoSite-Q99JW5
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TrEMBL |
Q8CG12
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UniProt Splice Variant |
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Entrez Gene |
17075
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UniGene |
Mm.476268
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RefSeq |
NP_032558
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MGI ID |
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MGI Symbol |
Epcam
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OMIM |
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CCDS |
CCDS29018
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HPRD |
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IMGT |
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EMBL |
AJ489452
AJ489453
AJ489454
AJ489455
AK145752
AK167182
BC005618
BC094465
M76124
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GenPept |
AAA37543
AAH05618
AAH94465
BAE26627
BAE39317
CAD33710
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