Version 5.4
Mus musculus Protein: Wls
Summary
InnateDB Protein IDBP-201451.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wls
Protein Name wntless homolog (Drosophila)
Synonyms 5031439A09Rik; AI173978; AI987742; Gpr177;
Species Mus musculus
Ensembl Protein ENSMUSP00000067898
InnateDB Gene IDBG-201449 (Wls)
Protein Structure
UniProt Annotation
Function Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development. {ECO:0000269PubMed:19841259}.
Subcellular Localization Golgi apparatus membrane {ECO:0000269PubMed:19841259}; Multi-pass membrane protein {ECO:0000269PubMed:19841259}. Cytoplasmic vesicle membrane {ECO:0000269PubMed:19841259}; Multi-pass membrane protein {ECO:0000269PubMed:19841259}.
Disease Associations
Tissue Specificity Expressed in kidney, lung, skin, intestine, brain, spinal cord, skeleton, eyes, excretion glands, tooth and palatal shelves. {ECO:0000269PubMed:19841259}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017147 Wnt-protein binding
GO:0031852 mu-type opioid receptor binding
Biological Process
GO:0001707 mesoderm formation
GO:0009948 anterior/posterior axis specification
GO:0016055 Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0032590 dendrite membrane
GO:0032839 dendrite cytoplasm
Protein Structure and Domains
PDB ID MGI:1915401
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6DID7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 68151
UniGene Mm.6766
RefSeq NP_080858
MGI ID
MGI Symbol Wls
OMIM
CCDS CCDS38684
HPRD
IMGT
EMBL AK019886 AK029053 AK029104 AK044810 AK049842 AK077407 AK159207 BC018381 BC075615
GenPept AAH18381 AAH75615 BAB31904 BAC26266 BAC26300 BAC32102 BAC33950 BAC36788 BAE34898

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca