InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fasl

Summary

InnateDB Protein

IDBP-201578.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fasl

Protein Name

Fas ligand (TNF superfamily, member 6)

Synonyms

APT1LG1; CD178; CD95-L; CD95L; Fas-L; Faslg; gld; Tnfsf6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000000834

InnateDB Gene

IDBG-201576 (Fasl)

Protein Structure

UniProt Annotation

Function

Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects (By similarity). {ECO:0000250}.The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition. {ECO:0000250}.

Subcellular Localization

Isoform FasL: Cell membrane; Single-pass type II membrane protein. Cytoplasmic vesicle lumen {ECO:0000250}. Lysosome lumen {ECO:0000250}. Note=Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination. Colocalizes with the SPPL2A protease at the cell membrane (By similarity). {ECO:0000250}.Isoform FasLS: Secreted.Tumor necrosis factor ligand superfamily member 6, soluble form: Secreted. Note=May be released into the extracellular fluid, probably by cleavage form the cell surface.FasL intracellular domain: Nucleus {ECO:0000250}. Note=The FasL ICD cytoplasmic form is translocated into the nucleus. {ECO:0000250}.

Disease Associations

Note=A deficiency in this protein is the cause of generalized lymphoproliferation disease phenotype (gld). Gld mice present lymphadenopathy and autoantibody production. The phenotype is recessively inherited.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	74 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005123	death receptor binding
GO:0005125	cytokine activity
GO:0005164	tumor necrosis factor receptor binding
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006925	inflammatory cell apoptotic process
GO:0006955	immune response
GO:0008284	positive regulation of cell proliferation
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors
GO:0016525	negative regulation of angiogenesis
GO:0030644	cellular chloride ion homeostasis
GO:0032496	response to lipopolysaccharide
GO:0043065	positive regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043525	positive regulation of neuron apoptotic process
GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway
GO:0046666	retinal cell programmed cell death
GO:0048388	endosomal lumen acidification
GO:0070231	T cell apoptotic process
GO:0070266	necroptotic process
GO:0070848	response to growth factor
GO:0097190	apoptotic signaling pathway
GO:0097191	extrinsic apoptotic signaling pathway
GO:0097527	necroptotic signaling pathway
GO:2000353	positive regulation of endothelial cell apoptotic process

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005901	caveola
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0043202	lysosomal lumen
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm
GO:0060205	cytoplasmic membrane-bounded vesicle lumen
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:99255

InterPro

IPR006052 Tumour necrosis factor domain
IPR006053 Tumour necrosis factor
IPR008983 Tumour necrosis factor-like domain
IPR028326 Tumor necrosis factor ligand superfamily member 6

PFAM

PF00229

PRINTS

PR01234
PR01681

PIRSF

SMART

SM00207

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt