InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dnm3

Summary

InnateDB Protein

IDBP-201704.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dnm3

Protein Name

dynamin 3

Synonyms

9630020E24Rik; AW061159; B230343F03Rik; C530045C17; mKIAA0820;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000064538

InnateDB Gene

IDBG-201700 (Dnm3)

Protein Structure

UniProt Annotation

Function

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Microtubule-associated. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006897	endocytosis
GO:0007416	synapse assembly
GO:0046847	filopodium assembly

Cellular Component

GO:0005739	mitochondrion
GO:0005874	microtubule
GO:0014069	postsynaptic density
GO:0043197	dendritic spine
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:1341299

InterPro

IPR000375 Dynamin central domain
IPR001401 Dynamin, GTPase domain
IPR001849 Pleckstrin homology domain
IPR003130 Dynamin GTPase effector
IPR022812 Dynamin superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01031
PF00350
PF00169
PF02212

PRINTS

PR00195

PIRSF

SMART

SM00053
SM00233
SM00302

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt