Version 5.4
Mus musculus Gene: Dnm3
Summary
InnateDB Gene IDBG-201700.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dnm3
Gene Name dynamin 3
Synonyms 9630020E24Rik; AW061159; B230343F03Rik; C530045C17; mKIAA0820
Species Mus musculus
Ensembl Gene ENSMUSG00000040265
Encoded Proteins
IDBP-201702
dynamin 3
IDBP-201704
dynamin 3
IDBP-532252
dynamin 3
IDBP-536387
dynamin 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197959:
Members of the dynamin family, such as DNM3, possess mechanochemical properties involved in actin-membrane processes, predominantly in membrane budding (Orth and McNiven, 2003 [PubMed 12517701]).[supplied by OMIM, Mar 2008]
This gene encodes a member of a family of guanosine triphosphate (GTP)-binding proteins that associate with microtubules and are involved in vesicular transport. The encoded protein functions in the development of megakaryocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:161982453-162478034
Strand Reverse strand
Band H2.1
Transcripts
ENSMUST00000086074 ENSMUSP00000083241
ENSMUST00000070330 ENSMUSP00000064538
ENSMUST00000159763 ENSMUSP00000125356
ENSMUST00000160665 ENSMUSP00000124593
ENSMUST00000161539
ENSMUST00000162330
ENSMUST00000160173
ENSMUST00000161155
ENSMUST00000161894
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006897 endocytosis
GO:0007416 synapse assembly
GO:0046847 filopodium assembly
Cellular Component
GO:0005739 mitochondrion
GO:0005874 microtubule
GO:0014069 postsynaptic density
GO:0043197 dendritic spine
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000197959
View Gene Order
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_257923
Recycling pathway of L1 pathway
REACT_230745
Immune System pathway
REACT_202778
Retrograde neurotrophin signalling pathway
REACT_196550
MHC class II antigen presentation pathway
REACT_261444
Axon guidance pathway
REACT_251547
Toll-Like Receptors Cascades pathway
REACT_219680
L1CAM interactions pathway
REACT_248921
Signalling by NGF pathway
REACT_229531
Adaptive Immune System pathway
REACT_188576
Developmental Biology pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_188257
Signal Transduction pathway
REACT_246719
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
mmu04144
Endocytosis pathway
mmu05100
Bacterial invasion of epithelial cells pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_121399
MHC class II antigen presentation pathway
REACT_12435
Retrograde neurotrophin signalling pathway
REACT_22365
Recycling pathway of L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_6802
Innate Immune System pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
KEGG
hsa04144
Endocytosis pathway
hsa05100
Bacterial invasion of epithelial cells pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.441620 Mm.447964
RefSeq NM_001038619 NM_172646
OMIM
CCDS CCDS48417
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca