InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lhcgr

Summary

InnateDB Protein

IDBP-201723.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lhcgr

Protein Name

luteinizing hormone/choriogonadotropin receptor

Synonyms

Gpcr19-rs1; LH-R; Lhr;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000024916

InnateDB Gene

IDBG-201721 (Lhcgr)

Protein Structure

UniProt Annotation

Function

Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004964	luteinizing hormone receptor activity
GO:0035472	choriogonadotropin hormone receptor activity
GO:0038106	choriogonadotropin hormone binding

Biological Process

GO:0001541	ovarian follicle development
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007283	spermatogenesis
GO:0008584	male gonad development
GO:0008585	female gonad development
GO:0022602	ovulation cycle process
GO:0032962	positive regulation of inositol trisphosphate biosynthetic process
GO:0042700	luteinizing hormone signaling pathway
GO:0043950	positive regulation of cAMP-mediated signaling
GO:0046544	development of secondary male sexual characteristics
GO:0060065	uterus development
GO:0071371	cellular response to gonadotropin stimulus
GO:0072520	seminiferous tubule development
GO:0090030	regulation of steroid hormone biosynthetic process

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:96783

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR002131 Glycoprotein hormone receptor family
IPR002273 Lutropin-choriogonadotropic hormone receptor
IPR002274 Thyrotropin receptor
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR00373
PR01144
PR01145

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P30730