Version 5.4
Mus musculus Protein: P2ry6
Summary
InnateDB Protein IDBP-201749.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol P2ry6
Protein Name pyrimidinergic receptor P2Y, G-protein coupled, 6
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000055697
InnateDB Gene IDBG-201747 (P2ry6)
Protein Structure
UniProt Annotation
Function Receptor for extracellular UTP > ADP = 2-methylthio-ATP > ADP-beta-S > ATP = ATP-gamma-S. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol- calcium second messenger system. Functionally coupled to phospholipase C (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0019103 pyrimidine nucleotide binding
GO:0045028 G-protein coupled purinergic nucleotide receptor activity
GO:0045029 UDP-activated nucleotide receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0014911 positive regulation of smooth muscle cell migration
GO:0030321 transepithelial chloride transport
GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway
Cellular Component
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
Protein Structure and Domains
PDB ID MGI:2673874
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000371 P2Y3 purinoceptor
IPR001973 P2Y6 purinoceptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019426 7TM GPCR, serpentine receptor class v (Srv)
PFAM PF00001
PF10323
PRINTS PR00237
PR01065
PR01068
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9ERK9
PhosphoSite PhosphoSite-
TrEMBL Q3UQ86
UniProt Splice Variant
Entrez Gene 233571
UniGene Mm.235193
RefSeq NP_898991
MGI ID
MGI Symbol P2ry6
OMIM
CCDS CCDS21507
HPRD
IMGT
EMBL AF298899 AK142680 BC027331 BC064095 CH466531
GenPept AAG24619 AAH27331 AAH64095 BAE25157 EDL16484

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca