Version 5.4
Mus musculus Protein: Sfswap
Summary
InnateDB Protein IDBP-201837.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sfswap
Protein Name splicing factor, suppressor of white-apricot homolog (Drosophila)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000062413
InnateDB Gene IDBG-201835 (Sfswap)
Protein Structure
UniProt Annotation
Function Plays a role as an alternative splicing regulator. Regulates its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10 (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0048025 negative regulation of mRNA splicing, via spliceosome
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:101760
InterPro IPR000061 SWAP/Surp
IPR019147 Suppressor of white apricot N-terminal domain
PFAM PF01805
PF09750
PRINTS
PIRSF
SMART SM00648
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3USH5
PhosphoSite PhosphoSite-Q3USH5
TrEMBL
UniProt Splice Variant
Entrez Gene 231769
UniGene
RefSeq NP_758480
MGI ID
MGI Symbol Sfswap
OMIM
CCDS CCDS19694
HPRD
IMGT
EMBL AC114614 AC114657 AK031872 AK140369
GenPept BAC27586 BAE24357

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca