InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Clcnka

Summary

InnateDB Protein

IDBP-202044.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Clcnka

Protein Name

chloride channel Ka

Synonyms

C75963; CLC-K1; Clcnk1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000048520

InnateDB Gene

IDBG-202042 (Clcnka)

Protein Structure

UniProt Annotation

Function

Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms. May be the basolateral chloride channel mediating net chloride absorption in CTAL cells.

Subcellular Localization

Membrane {ECO:0000269PubMed:11734858}; Multi-pass membrane protein {ECO:0000269PubMed:11734858}.

Disease Associations

Tissue Specificity

Specifically expressed in the kidney. All nephron segments expressing BSND also express CLCNK proreins. {ECO:0000269PubMed:11014860, ECO:0000269PubMed:11734858}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005247	voltage-gated chloride channel activity
GO:0005515	protein binding
GO:0030554	adenyl nucleotide binding
GO:0046872	metal ion binding

Biological Process

GO:0006821	chloride transport
GO:0034220	ion transmembrane transport
GO:0034765	regulation of ion transmembrane transport
GO:0044070	regulation of anion transport
GO:0050878	regulation of body fluid levels
GO:0055085	transmembrane transport
GO:0072053	renal inner medulla development
GO:1902476	chloride transmembrane transport