Version 5.4
Mus musculus Protein: Ppip5k1
Summary
InnateDB Protein IDBP-202059.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppip5k1
Protein Name diphosphoinositol pentakisphosphate kinase 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000057632
InnateDB Gene IDBG-202057 (Ppip5k1)
Protein Structure
UniProt Annotation
Function Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis- diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Relocalizes to the plasma membrane upon activation of the PtdIns 3-kinase pathway. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000827 inositol-1,3,4,5,6-pentakisphosphate kinase activity
GO:0000832 inositol hexakisphosphate 5-kinase activity
GO:0003993 acid phosphatase activity
GO:0005524 ATP binding
GO:0033857 diphosphoinositol-pentakisphosphate kinase activity
GO:0052723 inositol hexakisphosphate 1-kinase activity
GO:0052724 inositol hexakisphosphate 3-kinase activity
Biological Process
GO:0006020 inositol metabolic process
GO:0016310 phosphorylation
GO:0016311 dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:2443281
InterPro IPR000560 Histidine phosphatase superfamily, clade-2
IPR029033 Histidine phosphatase superfamily
PFAM PF00328
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A2ARP1
PhosphoSite PhosphoSite-A2ARP1
TrEMBL B0R0E7
UniProt Splice Variant
Entrez Gene 327655
UniGene Mm.386076
RefSeq NP_848910
MGI ID
MGI Symbol Ppip5k1
OMIM
CCDS CCDS16639
HPRD
IMGT
EMBL AF502585 AK046696 AK078268 AK083140 AK122264 AL845466 BC065138
GenPept AAH65138 AAP46293 BAC32838 BAC37198 BAC38780 BAC65546 CAM24220 CAM24221 CAM24222

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca