Version 5.4
Homo sapiens Protein: PELO
Summary
InnateDB Protein IDBP-20214.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PELO
Protein Name pelota homolog (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000274311
InnateDB Gene IDBG-20210 (PELO)
Protein Structure
UniProt Annotation
Function Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential). {ECO:0000250, ECO:0000305}.
Subcellular Localization Nucleus {ECO:0000305}. Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitously expressed. {ECO:0000269PubMed:11060452}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 26 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0007049 cell cycle
GO:0008283 cell proliferation
GO:0051276 chromosome organization
GO:0051301 cell division
GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay
GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay
GO:0071025 RNA surveillance
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR004405 Translation release factor pelota
IPR005140 eRF1 domain 1/Pelota-like
IPR005141 eRF1 domain 2
IPR005142 eRF1 domain 3
IPR029064 50S ribosomal protein L30e-like
PFAM PF03463
PF03464
PF03465
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BRX2
PhosphoSite PhosphoSite-Q9BRX2
TrEMBL
UniProt Splice Variant
Entrez Gene 53918
UniGene
RefSeq NP_057030
HUGO HGNC:8829
OMIM 605757
CCDS CCDS3956
HPRD 09309
IMGT
EMBL AC026230 AF132951 AF139828 AF143952 AY117399 BC005889 BC007249 BC007650 BC022789
GenPept AAD27726 AAG22574 AAG22575 AAH05889 AAH07249 AAH07650 AAH22789 AAM89414

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca