InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITGA1

Summary

InnateDB Protein

IDBP-20218.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGA1

Protein Name

integrin, alpha 1

Synonyms

CD49a; VLA1;

Species

Homo sapiens

Ensembl Protein

ENSP00000282588

InnateDB Gene

IDBG-236376 (ITGA1)

Protein Structure

UniProt Annotation

Function

Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. {ECO:0000269PubMed:15592458}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0019903	protein phosphatase binding
GO:0046872	metal ion binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0006936	muscle contraction
GO:0007155	cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0008285	negative regulation of cell proliferation
GO:0030198	extracellular matrix organization
GO:0030593	neutrophil chemotaxis
GO:0032516	positive regulation of phosphoprotein phosphatase activity
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0042311	vasodilation
GO:0043525	positive regulation of neuron apoptotic process
GO:0045123	cellular extravasation
GO:0048812	neuron projection morphogenesis
GO:0060326	cell chemotaxis

Cellular Component

GO:0001669	acrosomal vesicle
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0008305	integrin complex
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0043005	neuron projection
GO:0043204	perikaryon
GO:0045121	membrane raft
GO:0045178	basal part of cell
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000413 Integrin alpha chain
IPR002035 von Willebrand factor, type A
IPR013517 FG-GAP repeat
IPR013519 Integrin alpha beta-propellor
IPR013649 Integrin alpha-2

PFAM

PF00092
PF01839
PF14312
PF08441

PRINTS

PR01185

PIRSF

SMART

SM00327
SM00191

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt