InnateDB Protein
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IDBP-202239.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Catsper2
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Protein Name
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cation channel, sperm associated 2
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000037222
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InnateDB Gene
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IDBG-202235 (Catsper2)
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Protein Structure
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Function |
Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization. Contrary to the human ortholog, not activated by progesterone. {ECO:0000269PubMed:14657366, ECO:0000269PubMed:16036917, ECO:0000269PubMed:17174296}.
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Subcellular Localization |
Cell projection, cilium, flagellum membrane {ECO:0000269PubMed:11675491}; Multi-pass membrane protein {ECO:0000269PubMed:11675491}. Note=Specifically located in the principal piece of sperm tail.
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Disease Associations |
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Tissue Specificity |
Testis-specific. {ECO:0000269PubMed:11675491}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2387404
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InterPro |
IPR005821
Ion transport domain
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PFAM |
PF00520
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
212670
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UniGene |
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RefSeq |
NP_694715
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MGI ID |
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MGI Symbol |
Catsper2
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OMIM |
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CCDS |
CCDS38216
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HPRD |
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IMGT |
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EMBL |
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GenPept |
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