Version 5.4
Homo sapiens Protein: DKK4
Summary
InnateDB Protein IDBP-20227.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DKK4
Protein Name dickkopf homolog 4 (Xenopus laevis)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000220812
InnateDB Gene IDBG-20225 (DKK4)
Protein Structure
UniProt Annotation
Function Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Expressed in cerebellum, T-cells, esophagus and lung.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0007275 multicellular organismal development
GO:0016055 Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
Cellular Component
GO:0005575 cellular_component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR006796 Dickkopf, N-terminal cysteine-rich
IPR023569 Prokineticin domain
PFAM PF04706
PF06607
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UBT3
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 27121
UniGene
RefSeq NP_055235
HUGO HGNC:2894
OMIM 605417
CCDS CCDS6130
HPRD 05660
IMGT
EMBL AB017788 AB018005 AF177397 BC107046 BC107047
GenPept AAF02677 AAI07047 AAI07048 BAA33438 BAA33475

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca