InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pdia3

Summary

InnateDB Protein

IDBP-202295.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pdia3

Protein Name

protein disulfide isomerase associated 3

Synonyms

58kDa; Erp; ERp57; ERp60; ERp61; Grp58; PDI; PDI-Q2; PI-PLC; PLC[a]; Plca;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028683

InnateDB Gene

IDBG-202293 (Pdia3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Endoplasmic reticulum {ECO:0000250}. Endoplasmic reticulum lumen {ECO:0000250}. Melanosome {ECO:0000250}.

Disease Associations

Tissue Specificity

In caput and cauda epididymal spermatozoa, detected in the acrosome and principal piece (at protein level). {ECO:0000269PubMed:20400973}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	60 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003756	protein disulfide isomerase activity
GO:0005515	protein binding
GO:0016853	isomerase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006457	protein folding
GO:0034976	response to endoplasmic reticulum stress
GO:0045454	cell redox homeostasis
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005790	smooth endoplasmic reticulum
GO:0009986	cell surface
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome