InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pdia3

Summary

InnateDB Gene

IDBG-202293.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pdia3

Gene Name

protein disulfide isomerase associated 3

Synonyms

58kDa; Erp; ERp57; ERp60; ERp61; Grp58; PDI; PDI-Q2; PI-PLC; PLC[a]; Plca

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027248

Encoded Proteins

IDBP-202295

protein disulfide isomerase associated 3

IDBP-541781

protein disulfide isomerase associated 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167004:
This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:121413775-121438687

Strand

Forward strand

Band

Transcripts

ENSMUST00000028683	ENSMUSP00000028683
ENSMUST00000153378
ENSMUST00000135079	ENSMUSP00000119337
ENSMUST00000130450

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 60 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	60 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003756	protein disulfide isomerase activity
GO:0005515	protein binding
GO:0015035	protein disulfide oxidoreductase activity
GO:0016853	isomerase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006457	protein folding
GO:0006662	glycerol ether metabolic process
GO:0034976	response to endoplasmic reticulum stress
GO:0045454	cell redox homeostasis
GO:0055114	oxidation-reduction process
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005790	smooth endoplasmic reticulum
GO:0009986	cell surface
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome