InnateDB Protein
|
IDBP-202317.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Lamtor1
|
Protein Name
|
RIKEN cDNA 2400001E08 gene
|
Synonyms
|
2400001E08Rik; p18; Pdro;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000033131
|
InnateDB Gene
|
IDBG-202315 (Lamtor1)
|
Protein Structure
|
|
Function |
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation. {ECO:0000269PubMed:19177150}.
|
Subcellular Localization |
Late endosome membrane {ECO:0000250}; Lipid- anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Lysosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell membrane {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Experimentally validated |
Total |
8
[view]
|
Protein-Protein |
8
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
32 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:1913758
|
InterPro |
|
PFAM |
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9CQ22
|
PhosphoSite |
PhosphoSite-Q9CQ22
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
66508
|
UniGene |
Mm.460610
|
RefSeq |
NP_079881
|
MGI ID |
|
MGI Symbol |
Lamtor1
|
OMIM |
|
CCDS |
CCDS21519
|
HPRD |
|
IMGT |
|
EMBL |
AK009320
AK013389
AK019947
AK144476
BC020142
BC092062
BC096412
BC115458
BC115459
BC126973
|
GenPept |
AAH20142
AAH92062
AAH96412
AAI26974
BAB26214
BAB28825
BAB31928
BAE25909
|
|
|