InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atp1b1

Summary

InnateDB Protein

IDBP-202515.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp1b1

Protein Name

ATPase, Na+/K+ transporting, beta 1 polypeptide

Synonyms

Atp4b; Atpb; Atpb-1; NKbeta1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027863

InnateDB Gene

IDBG-202513 (Atp1b1)

Protein Structure

UniProt Annotation

Function

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.Involved in cell adhesion and establishing epithelial cell polarity. {ECO:0000250}.

Subcellular Localization

Cell membrane; Single-pass type II membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005391	sodium:potassium-exchanging ATPase activity
GO:0005515	protein binding
GO:0023026	MHC class II protein complex binding

Biological Process

GO:0001666	response to hypoxia
GO:0006813	potassium ion transport
GO:0006814	sodium ion transport
GO:0007155	cell adhesion
GO:0030001	metal ion transport
GO:0035725	sodium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005890	sodium:potassium-exchanging ATPase complex
GO:0005901	caveola
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0070062	extracellular vesicular exosome