InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Atp1b1

Summary

InnateDB Gene

IDBG-202513.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atp1b1

Gene Name

ATPase, Na+/K+ transporting, beta 1 polypeptide

Synonyms

Atp4b; Atpb; Atpb-1; NKbeta1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026576

Encoded Proteins

IDBP-202515

ATPase, Na+/K+ transporting, beta 1 polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes an integral membrane protein that comprises a subunit of an ATP-metabolizing enzyme responsible for transporting sodium and potassium ions across the plasma membrane. This enzyme regulates the electrochemical gradient of these ions in cells, and plays a central role in osmoregulation and signal transmission in nerves and muscles, among other biological processes. The encoded protein is the non-catalytic beta subunit; it works together with a catalytic alpha subunit and a gamma subunit. [provided by RefSeq, Mar 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:164437267-164458355

Strand

Reverse strand

Band

H2.2

Transcripts

ENSMUST00000027863

ENSMUSP00000027863

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005391	sodium:potassium-exchanging ATPase activity
GO:0005515	protein binding
GO:0023026	MHC class II protein complex binding

Biological Process

GO:0001666	response to hypoxia
GO:0006813	potassium ion transport
GO:0006814	sodium ion transport
GO:0007155	cell adhesion
GO:0030001	metal ion transport
GO:0035725	sodium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005890	sodium:potassium-exchanging ATPase complex
GO:0005901	caveola
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0070062	extracellular vesicular exosome