Version 5.4
Mus musculus Protein: Tiprl
Summary
InnateDB Protein IDBP-202597.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tiprl
Protein Name TIP41, TOR signalling pathway regulator-like (S. cerevisiae)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000037514
InnateDB Gene IDBG-202595 (Tiprl)
Protein Structure
UniProt Annotation
Function May be a allosteric regulator of serine/threonine- protein phosphatase 2A (PP2A). Inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0000077 DNA damage checkpoint
GO:0034048 negative regulation of protein phosphatase type 2A activity
Cellular Component
GO:0005737 cytoplasm
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID MGI:1915087
InterPro IPR007303 TIP41-like protein
PFAM PF04176
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BH58
PhosphoSite PhosphoSite-Q8BH58
TrEMBL
UniProt Splice Variant
Entrez Gene 226591
UniGene Mm.413841
RefSeq NP_663488
MGI ID
MGI Symbol Tiprl
OMIM
CCDS CCDS15441
HPRD
IMGT
EMBL AK049119 AK049784 AK075774 BC002098 BC058250
GenPept AAH02098 AAH58250 BAC33553 BAC33919 BAC35948

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca