InnateDB Protein
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IDBP-202638.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Gtf2i
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Protein Name
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general transcription factor II I
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Synonyms
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6030441I21Rik; BAP-135; Diws1t; GtfII-I; Spin; TFII-I; WBSCR6;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000049625
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InnateDB Gene
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IDBG-202636 (Gtf2i)
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Protein Structure
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Function |
Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C- FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box (By similarity). Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B- lymphocyte activation. {ECO:0000250, ECO:0000269PubMed:16738337}.
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Subcellular Localization |
Cytoplasm. Nucleus. Note=Colocalizes with BTK in the cytoplasm. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
62 [view]
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Molecular Function |
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0014886
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transition between slow and fast fiber
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GO:0016525
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negative regulation of angiogenesis
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GO:0051481
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negative regulation of cytosolic calcium ion concentration
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Cellular Component |
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PDB ID |
MGI:1202722
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InterPro |
IPR004212
GTF2I-like repeat
IPR016659
Transcription factor II-I
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PFAM |
PF02946
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PRINTS |
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PIRSF |
PIRSF016441
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9ESZ8
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PhosphoSite |
PhosphoSite-Q9ESZ8
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TrEMBL |
G3UZU4
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UniProt Splice Variant |
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Entrez Gene |
14886
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UniGene |
Mm.261570
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RefSeq |
NP_001074215
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MGI ID |
1Q60
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MGI Symbol |
Gtf2i
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OMIM |
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CCDS |
CCDS39301
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HPRD |
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IMGT |
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EMBL |
AC093346
AF017085
AF043219
AF043220
AF289666
AF325177
AK006796
AK013348
AY030290
AY030291
AY030292
AY030293
BC053044
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GenPept |
AAC02990
AAC02991
AAC53569
AAF99338
AAH53044
AAK49785
AAK49786
AAK49787
AAK49788
BAB24743
BAB28803
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