InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Adcy10

Summary

InnateDB Protein

IDBP-202674.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adcy10

Protein Name

adenylate cyclase 10

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027852

InnateDB Gene

IDBG-202672 (Adcy10)

Protein Structure

UniProt Annotation

Function

Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. {ECO:0000269PubMed:14976244, ECO:0000269PubMed:16054031}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:12475901}; Peripheral membrane protein {ECO:0000269PubMed:12475901}; Cytoplasmic side {ECO:0000269PubMed:12475901}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:12475901}. Cytoplasm, perinuclear region {ECO:0000269PubMed:12475901}. Note=Distributed to subcellular compartments containing cAMP targets. Found as a plasma membrane-associated protein, protein concentrated in the perinuclear region and protein colocalized with actin or tubulin (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in testis. {ECO:0000269PubMed:16054031}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004016	adenylate cyclase activity
GO:0005524	ATP binding
GO:0016849	phosphorus-oxygen lyase activity
GO:0030145	manganese ion binding
GO:0051117	ATPase binding

Biological Process

GO:0006171	cAMP biosynthetic process
GO:0007283	spermatogenesis
GO:0009190	cyclic nucleotide biosynthetic process
GO:0035556	intracellular signal transduction
GO:0043065	positive regulation of apoptotic process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0030426	growth cone
GO:0043025	neuronal cell body
GO:0045177	apical part of cell
GO:0045178	basal part of cell
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:2660854

InterPro

IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
IPR016577 Adenylate cylcase, type 10
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00211

PRINTS

PIRSF

PIRSF011131

SMART

SM00044

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt