InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CREBL2

Summary

InnateDB Protein

IDBP-20281.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CREBL2

Protein Name

cAMP responsive element binding protein-like 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000228865

InnateDB Gene

IDBG-20279 (CREBL2)

Protein Structure

UniProt Annotation

Function

Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor. {ECO:0000269PubMed:9693048}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	0
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007049	cell cycle
GO:0007165	signal transduction
GO:0030154	cell differentiation
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0045600	positive regulation of fat cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046326	positive regulation of glucose import
GO:0046889	positive regulation of lipid biosynthetic process
GO:0050821	protein stabilization