InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CREBL2

Summary

InnateDB Gene

IDBG-20279.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CREBL2

Gene Name

cAMP responsive element binding protein-like 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000111269

Encoded Proteins

IDBP-20281

cAMP responsive element binding protein-like 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. [provided by RefSeq, Jul 2008]
cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41%% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:12611827-12645108

Strand

Forward strand

Band

p13.1

Transcripts

ENST00000228865	ENSP00000228865
ENST00000540224

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	0
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007049	cell cycle
GO:0007165	signal transduction
GO:0030154	cell differentiation
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0045600	positive regulation of fat cell differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046326	positive regulation of glucose import
GO:0046889	positive regulation of lipid biosynthetic process
GO:0050821	protein stabilization

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000032652

View Gene Order

ENSBTAG00000011957

Not yet available

Cross-References

SwissProt

O60519

TrEMBL

UniProt Splice Variant

Entrez Gene

1389

UniGene

Hs.13313 Hs.591156

RefSeq

NM_001310

HUGO

HGNC:2350

OMIM

603476

CCDS

CCDS8651

HPRD

IMGT

EMBL

AB451461 AF039081 BC104873 BC106052 BC112157 CH471094 CR542250

GenPept

AAC32314 AAI04874 AAI06053 AAI12158 BAG70275 CAG47046 EAW96269

RNA Seq Atlas

1389