InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Duox1

Summary

InnateDB Protein

IDBP-202933.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Duox1

Protein Name

dual oxidase 1

Synonyms

9930101G15Rik; AW987690; Duox2; LNOX1; LNOX2; NOXEF1; NOXEF2; P138-TOX; THOX1; THOX2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000097060

InnateDB Gene

IDBG-202931 (Duox1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004601	peroxidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0020037	heme binding

Biological Process

GO:0006979	response to oxidative stress
GO:0019221	cytokine-mediated signaling pathway
GO:0042335	cuticle development
GO:0055114	oxidation-reduction process
GO:0072593	reactive oxygen species metabolic process

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2139422

InterPro

IPR002007 Haem peroxidase, animal
IPR002048 EF-hand domain
IPR010255 Haem peroxidase
IPR013112 FAD-binding 8
IPR013121 Ferric reductase, NAD binding
IPR013130 Ferric reductase transmembrane component-like domain
IPR017938 Riboflavin synthase-like beta-barrel
IPR019791 Haem peroxidase, animal, subgroup

PFAM