Version 5.4
Mus musculus Gene: Duox1
Summary
InnateDB Gene IDBG-202931.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Duox1
Gene Name dual oxidase 1
Synonyms 9930101G15Rik; AW987690; Duox2; LNOX1; LNOX2; NOXEF1; NOXEF2; P138-TOX; THOX1; THOX2
Species Mus musculus
Ensembl Gene ENSMUSG00000033268
Encoded Proteins
IDBP-202933
dual oxidase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 18511861
[Homo sapiens] DUOX1 and DUOX2 localize to the apical plasma membrane of epithelial cells in major airways, salivary glands, and the gastrointestinal tract, and provide extracellular hydrogen peroxide to lactoperoxidase to produce antimicrobial hypothiocyanite ions. Expression of dual oxidases DUOX2 and DUOX1 is regulated by Th1 and Th2 cytokines in human airways.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137857:
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:122315672-122347972
Strand Forward strand
Band E5
Transcripts
ENSMUST00000099461 ENSMUSP00000097060
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004601 peroxidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0020037 heme binding
Biological Process
GO:0006979 response to oxidative stress
GO:0019221 cytokine-mediated signaling pathway
GO:0042335 cuticle development
GO:0055114 oxidation-reduction process
GO:0072593 reactive oxygen species metabolic process
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000137857
View Gene Order
ENSBTAG00000016246
Not yet available
Cross-References
SwissProt
TrEMBL A2AQ92
UniProt Splice Variant
Entrez Gene 99439
UniGene Mm.108582
RefSeq NM_001099297 XM_006500487
OMIM
CCDS CCDS38222
HPRD
IMGT
MGI ID MGI:2139422
MGI Symbol Duox1
EMBL AL844566
GenPept
RNA Seq Atlas 99439

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca