Version 5.4
Mus musculus Protein: Eif4h
Summary
InnateDB Protein IDBP-203013.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eif4h
Protein Name eukaryotic translation initiation factor 4H
Synonyms AU018978; D5Ertd355e; E430026L18Rik; Ef4h; mKIAA0038; Wbscr1; Wscr1;
Species Mus musculus
Ensembl Protein ENSMUSP00000048833
InnateDB Gene IDBG-203011 (Eif4h)
Protein Structure
UniProt Annotation
Function Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, perinuclear region.
Disease Associations
Tissue Specificity Expressed at high levels in heart, liver and testis and at lower levels in brain, spleen, lung, skeletal muscle, kidney and embryonic tissues. Both isoforms are expressed at similar levels. {ECO:0000269PubMed:11003705}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006413 translational initiation
GO:0019953 sexual reproduction
GO:0048589 developmental growth
Cellular Component
GO:0016020 membrane
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:1341822
InterPro IPR000504 RNA recognition motif domain
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WUK2
PhosphoSite PhosphoSite-Q9WUK2
TrEMBL Q9ET00
UniProt Splice Variant
Entrez Gene 22384
UniGene Mm.428932
RefSeq NP_291039
MGI ID 2DNG
MGI Symbol Eif4h
OMIM
CCDS CCDS19723
HPRD
IMGT
EMBL AF139987 AF289664 AF289665 AK045004 AK088818 AK135390 AK136999 AK149841 AK150088 AK166567 AK168872 AK169312 AK169353 AK169407 BC014796 CH466529
GenPept AAD34859 AAD34860 AAF99330 AAF99335 AAH14796 BAC32180 BAC40593 BAE22517 BAE23201 BAE29116 BAE29297 BAE38858 BAE40690 BAE41067 BAE41102 BAE41153 EDL19418 EDL19419

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca