Version 5.4
Homo sapiens Protein: CHRNB3
Summary
InnateDB Protein IDBP-20316.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHRNB3
Protein Name cholinergic receptor, nicotinic, beta 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000289957
InnateDB Gene IDBG-20314 (CHRNB3)
Protein Structure
UniProt Annotation
Function After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular Localization Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004889 acetylcholine-activated cation-selective channel activity
GO:0005230 extracellular ligand-gated ion channel activity
GO:0008144 drug binding
GO:0015267 channel activity
GO:0042166 acetylcholine binding
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006812 cation transport
GO:0007165 signal transduction
GO:0007268 synaptic transmission
GO:0007271 synaptic transmission, cholinergic
GO:0034220 ion transmembrane transport
GO:0051291 protein heterooligomerization
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005892 acetylcholine-gated channel complex
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0043005 neuron projection
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID
InterPro IPR002394 Nicotinic acetylcholine receptor
IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding
PFAM PF02932
PF02931
PRINTS PR00254
PR00252
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q05901
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 1142
UniGene Hs.654576
RefSeq NP_000740
HUGO HGNC:1963
OMIM 118508
CCDS CCDS6134
HPRD 00336
IMGT
EMBL AF140760 AF140761 AF140762 AF140763 AF140764 AF140765 BC069681 BC069703 BC069788 U62438 X67513 Y08417
GenPept AAB40116 AAD33063 AAH69681 AAH69703 AAH69788 CAA47851 CAA69694

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca