InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc30a4

Summary

InnateDB Protein

IDBP-203167.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc30a4

Protein Name

solute carrier family 30 (zinc transporter), member 4

Synonyms

lm; znT-4; Znt4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000005952

InnateDB Gene

IDBG-203165 (Slc30a4)

Protein Structure

UniProt Annotation

Function

Probably involved in zinc transport out of the cytoplasm, may be by sequestration into an intracellular compartment.

Subcellular Localization

Endosome membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Note=Defects in Slc30a4 are the cause of the lethal milk (lm) phenotype. Mice with lm are defective in zinc transport into breast milk, due to a premature translation termination codon at position 297. Only homozygous mutant adults develop dermatitis, skin lesions, and hair loss due to a systemic zinc deficiency. However, neonatal mice (of any genotype) suckled on homozygous mutant female also develop symptoms characteristic of nutritional zinc deficiency, including dermatitis, alopecia and stunted growth.

Tissue Specificity

Widely expressed. Highly expressed in the brain and in mammary epithelial cell lines.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008324	cation transmembrane transporter activity

Biological Process

GO:0006812	cation transport
GO:0006829	zinc ion transport
GO:0009636	response to toxic substance
GO:0055069	zinc ion homeostasis
GO:0055085	transmembrane transport
GO:0061088	regulation of sequestering of zinc ion