InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tnfrsf1b

Summary

InnateDB Protein

IDBP-203279.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnfrsf1b

Protein Name

tumor necrosis factor receptor superfamily, member 1b

Synonyms

CD120b; p75; TNF-alphaR2; TNF-R-II; TNF-R2; TNF-R75; TNFalpha-R2; TNFBR; Tnfr-1; Tnfr2; TNFR80; TNFRII;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030336

InnateDB Gene

IDBG-203277 (Tnfrsf1b)

Protein Structure

UniProt Annotation

Function

Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2 (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 106 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	106 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005031	tumor necrosis factor-activated receptor activity
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0006954	inflammatory response
GO:0006955	immune response
GO:0007166	cell surface receptor signaling pathway
GO:0007568	aging
GO:0008283	cell proliferation
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0032496	response to lipopolysaccharide
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0050728	negative regulation of inflammatory response
GO:0050779	RNA destabilization
GO:0051044	positive regulation of membrane protein ectodomain proteolysis
GO:0071222	cellular response to lipopolysaccharide
GO:0071363	cellular response to growth factor stimulus
GO:0097191	extrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030424	axon
GO:0043025	neuronal cell body
GO:0043196	varicosity
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm