Version 5.4
Mus musculus Protein: Fbxl2
Summary
InnateDB Protein IDBP-203316.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fbxl2
Protein Name F-box and leucine-rich repeat protein 2
Synonyms 2810423A21Rik; Fbl3;
Species Mus musculus
Ensembl Protein ENSMUSP00000035090
InnateDB Gene IDBG-203314 (Fbxl2)
Protein Structure
UniProt Annotation
Function Calcium-activated substrate recognition component of a SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 doesn't seem to target phosphodegron within its substrates but rather calmodulin-binding motifs. Targets PCYT1A for its monoubiquitination and degradation, this is antagonized by calmodulin. Targets the cyclins CCND2 and CCND3 for polyubiquitination and degradation, leading to cell-cycle arrest in G(0), also antagonized by calmodulin (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006513 protein monoubiquitination
Cellular Component
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:1919429
InterPro IPR001611 Leucine-rich repeat
IPR001810 F-box domain
IPR006553 Leucine-rich repeat, cysteine-containing subtype
PFAM PF00560
PF13504
PF13855
PF00646
PF12937
PF13013
PRINTS
PIRSF
SMART SM00256
SM00367
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BH16
PhosphoSite PhosphoSite-
TrEMBL Q4VA21
UniProt Splice Variant
Entrez Gene 72179
UniGene Mm.386808
RefSeq NP_848739
MGI ID
MGI Symbol Fbxl2
OMIM
CCDS CCDS40790
HPRD
IMGT
EMBL AK039010 AK044693 AK045742 AK089994 AK141177 BC096582 BC145665 BC145998 CH466621
GenPept AAH96582 AAI45666 AAI45999 BAC30203 BAC32036 BAC32477 BAC41033 BAE24574 EDL08941

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca