Version 5.4
Mus musculus Gene: Fbxl2
Summary
InnateDB Gene IDBG-203314.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fbxl2
Gene Name F-box and leucine-rich repeat protein 2
Synonyms 2810423A21Rik; Fbl3
Species Mus musculus
Ensembl Gene ENSMUSG00000032507
Encoded Proteins
IDBP-203316
F-box and leucine-rich repeat protein 2
IDBP-400286
F-box and leucine-rich repeat protein 2
IDBP-536719
F-box and leucine-rich repeat protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000153558:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:113963637-114046191
Strand Reverse strand
Band F3
Transcripts
ENSMUST00000035090 ENSMUSP00000035090
ENSMUST00000117537 ENSMUSP00000114075
ENSMUST00000143180 ENSMUSP00000117058
ENSMUST00000139757
ENSMUST00000127352
ENSMUST00000141832
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006513 protein monoubiquitination
Cellular Component
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000153558
View Gene Order
ENSBTAG00000003952
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.386808
RefSeq NM_178624
OMIM
CCDS CCDS40790
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca