InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc24a5

Summary

InnateDB Protein

IDBP-203361.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc24a5

Protein Name

solute carrier family 24, member 5

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000063887

InnateDB Gene

IDBG-203359 (Slc24a5)

Protein Structure

UniProt Annotation

Function

Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium- Calcium exchanger in melanocytes. Probably transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+) (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Melanosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in melanin-producing cells such as skin and eye compared to other tissues. Strongly overexpressed in melanoma cell lines. Expressed in dental tissues. {ECO:0000269PubMed:16357253, ECO:0000269PubMed:22677781}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008273	calcium, potassium:sodium antiporter activity
GO:0015293	symporter activity

Biological Process

GO:0006813	potassium ion transport
GO:0006816	calcium ion transport
GO:0034220	ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0048022	negative regulation of melanin biosynthetic process
GO:0050896	response to stimulus
GO:0055085	transmembrane transport