InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pbx1

Summary

InnateDB Protein

IDBP-203381.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pbx1

Protein Name

pre B-cell leukemia transcription factor 1

Synonyms

2310056B04Rik; D230003C07Rik; Pbx-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000066385

InnateDB Gene

IDBG-203379 (Pbx1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	28 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001655	urogenital system development
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0008284	positive regulation of cell proliferation
GO:0009887	organ morphogenesis
GO:0009952	anterior/posterior pattern specification
GO:0009954	proximal/distal pattern formation
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle
GO:0030278	regulation of ossification
GO:0030325	adrenal gland development
GO:0030326	embryonic limb morphogenesis
GO:0035162	embryonic hemopoiesis
GO:0042127	regulation of cell proliferation
GO:0045665	negative regulation of neuron differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048536	spleen development
GO:0048538	thymus development
GO:0048568	embryonic organ development
GO:0048706	embryonic skeletal system development

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:97495

InterPro

IPR001356 Homeobox domain
IPR005542 PBX
IPR009057 Homeodomain-like

PFAM

PF00046
PF03792

PRINTS

PIRSF

SMART

SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

D9J2V6

UniProt Splice Variant

Entrez Gene

18514

UniGene

Mm.462252

RefSeq

NP_001278438

MGI ID

MGI Symbol

Pbx1

OMIM

CCDS

HPRD

IMGT

EMBL

AC093320 AC096625 AC112152 AC116129 HM369110

GenPept

ADK11716