Version 5.4
Mus musculus Gene: Pbx1
Summary
InnateDB Gene IDBG-203379.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pbx1
Gene Name pre B cell leukemia homeobox 1
Synonyms 2310056B04Rik; D230003C07Rik; Pbx-1
Species Mus musculus
Ensembl Gene ENSMUSG00000052534
Encoded Proteins
IDBP-203381
pre B-cell leukemia transcription factor 1
IDBP-203385
pre B-cell leukemia transcription factor 1
IDBP-714604
IDBP-716568
IDBP-715224
IDBP-787720
pre B cell leukemia homeobox 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a homeobox protein that belongs to the three-amino-acid loop extension/Pre-B cell leukemia transcription factor (TALE/PBX) family of proteins. The encoded protein is involved in several biological processes during embryogenesis including steroidogenesis, sexual development and the maintenance of hematopoietic stem cells. This protein functions in the development of several organ systems and plays a role in skeletal patterning and programming. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:168119364-168432270
Strand Reverse strand
Band H2.3
Transcripts
ENSMUST00000064438 ENSMUSP00000066385
ENSMUST00000097471
ENSMUST00000072863 ENSMUSP00000072640
ENSMUST00000176482
ENSMUST00000176540 ENSMUSP00000135516
ENSMUST00000176791
ENSMUST00000176790 ENSMUSP00000134925
ENSMUST00000176309 ENSMUSP00000135046
ENSMUST00000188912 ENSMUSP00000140606
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 28 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 35 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001655 urogenital system development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006694 steroid biosynthetic process
GO:0007548 sex differentiation
GO:0008284 positive regulation of cell proliferation
GO:0009887 organ morphogenesis
GO:0009952 anterior/posterior pattern specification
GO:0009954 proximal/distal pattern formation
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0030278 regulation of ossification
GO:0030325 adrenal gland development
GO:0030326 embryonic limb morphogenesis
GO:0035162 embryonic hemopoiesis
GO:0042127 regulation of cell proliferation
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045665 negative regulation of neuron differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048536 spleen development
GO:0048538 thymus development
GO:0048568 embryonic organ development
GO:0048706 embryonic skeletal system development
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000185630
View Gene Order
ENSBTAG00000013801
Not yet available
Pathways
NETPATH
REACTOME
REACT_216222
Transcriptional regulation of pluripotent stem cells pathway
REACT_188576
Developmental Biology pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_111045
Developmental Biology pathway
REACT_200812
Transcriptional regulation of pluripotent stem cells pathway
KEGG
INOH
PID NCI
reg_gr_pathway
Glucocorticoid receptor regulatory network
Cross-References
SwissProt
TrEMBL Q71VB4 Q99LS8
UniProt Splice Variant
Entrez Gene 18514
UniGene
RefSeq NM_008783 NM_183355
OMIM
CCDS CCDS15462 CCDS15461
HPRD
IMGT
MGI ID MGI:97495
MGI Symbol Pbx1
EMBL AF020197 BC002244
GenPept AAB71192 AAH02244
RNA Seq Atlas 18514

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca