InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pbx1

Summary

InnateDB Protein

IDBP-203385.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pbx1

Protein Name

pre B-cell leukemia transcription factor 1

Synonyms

2310056B04Rik; D230003C07Rik; Pbx-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000072640

InnateDB Gene

IDBG-203379 (Pbx1)

Protein Structure

UniProt Annotation

Function

Plays a role in the cAMP-dependent regulation of CYP17 gene expression via its cAMP-regulatory sequence (CRS1) 5'- ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4. Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B. Together with NKX2-5, it is required for spleen development through a mechanism that involves CDKN2B repression. {ECO:0000269PubMed:22560297}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Widely distributed in steroidogenic and non- steroidogenic cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	28 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001655	urogenital system development
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006694	steroid biosynthetic process
GO:0007548	sex differentiation
GO:0008284	positive regulation of cell proliferation
GO:0009887	organ morphogenesis
GO:0009952	anterior/posterior pattern specification
GO:0009954	proximal/distal pattern formation
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle
GO:0030278	regulation of ossification
GO:0030325	adrenal gland development
GO:0030326	embryonic limb morphogenesis
GO:0035162	embryonic hemopoiesis
GO:0042127	regulation of cell proliferation
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045665	negative regulation of neuron differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048536	spleen development
GO:0048538	thymus development
GO:0048568	embryonic organ development
GO:0048706	embryonic skeletal system development