Version 5.4
Mus musculus Protein: Nuf2
Summary
InnateDB Protein IDBP-203465.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nuf2
Protein Name NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
Synonyms 2410003C07Rik; AU044112; C85691; Cdca1; NUF2R;
Species Mus musculus
Ensembl Protein ENSMUSP00000028000
InnateDB Gene IDBG-203463 (Nuf2)
Protein Structure
UniProt Annotation
Function Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0007067 mitotic nuclear division
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
GO:0031262 Ndc80 complex
Protein Structure and Domains
PDB ID MGI:1914227
InterPro IPR005549 Kinetochore protein Nuf2
PFAM PF03800
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99P69
PhosphoSite PhosphoSite-Q99P69
TrEMBL
UniProt Splice Variant
Entrez Gene 66977
UniGene Mm.350612
RefSeq XP_006497021
MGI ID
MGI Symbol Nuf2
OMIM
CCDS CCDS15463
HPRD
IMGT
EMBL AF326732 AK012011 AK089939 AK132467 AK162249 BC020026
GenPept AAH20026 AAK01427 BAB27973 BAC41008 BAE21183 BAE36815

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca