Version 5.4
Mus musculus Protein: Hsd17b7
Summary
InnateDB Protein IDBP-203566.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hsd17b7
Protein Name hydroxysteroid (17-beta) dehydrogenase 7
Synonyms AI266814; ERG27;
Species Mus musculus
Ensembl Protein ENSMUSP00000027989
InnateDB Gene IDBG-203564 (Hsd17b7)
Protein Structure
UniProt Annotation
Function Responsible for the reduction of the keto group on the C-3 of sterols.
Subcellular Localization Cell membrane; Single-pass membrane protein.
Disease Associations
Tissue Specificity Most abundant in ovaries of pregnant animals. Present also in nonpregnant animals in ovaries, mammary gland, liver, kidney and testis.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000253 3-keto sterol reductase activity
GO:0004303 estradiol 17-beta-dehydrogenase activity
GO:0005148 prolactin receptor binding
GO:0016491 oxidoreductase activity
Biological Process
GO:0006695 cholesterol biosynthetic process
GO:0006703 estrogen biosynthetic process
GO:0008152 metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1330808
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR013968 Polyketide synthase, KR
PFAM PF00106
PF08659
PRINTS PR00080
PR00081
PIRSF PIRSF000126
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O88736
PhosphoSite PhosphoSite-O88736
TrEMBL
UniProt Splice Variant
Entrez Gene 15490
UniGene Mm.474133
RefSeq NP_034606
MGI ID
MGI Symbol Hsd17b7
OMIM
CCDS CCDS35766
HPRD
IMGT
EMBL AF367475 AJ291459 AJ291460 AJ291461 AJ291462 AJ291463 AJ291464 AJ291465 AJ291466 AK028380 AK050211 BC011464 Y15733
GenPept AAM21211 BAC25918 BAC34124 CAA75742 CAC88119

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca