Version 5.4
Mus musculus Gene: Hsd17b7
Summary
InnateDB Gene IDBG-203564.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hsd17b7
Gene Name hydroxysteroid (17-beta) dehydrogenase 7
Synonyms AI266814; ERG27
Species Mus musculus
Ensembl Gene ENSMUSG00000026675
Encoded Proteins
IDBP-203566
hydroxysteroid (17-beta) dehydrogenase 7
IDBP-258315
hydroxysteroid (17-beta) dehydrogenase 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000132196:
HSD17B7 encodes an enzyme that functions both as a 17-beta-hydroxysteroid dehydrogenase (EC 1.1.1.62) in the biosynthesis of sex steroids and as a 3-ketosteroid reductase (EC 1.1.1.270) in the biosynthesis of cholesterol (Marijanovic et al., 2003 [PubMed 12829805]).[supplied by OMIM, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:169949535-169969241
Strand Reverse strand
Band H3
Transcripts
ENSMUST00000027989 ENSMUSP00000027989
ENSMUST00000111353 ENSMUSP00000106985
ENSMUST00000133563
ENSMUST00000123230
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000253 3-keto sterol reductase activity
GO:0004303 estradiol 17-beta-dehydrogenase activity
GO:0005148 prolactin receptor binding
GO:0016491 oxidoreductase activity
Biological Process
GO:0006695 cholesterol biosynthetic process
GO:0006703 estrogen biosynthetic process
GO:0008152 metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000132196
View Gene Order
ENSBTAG00000005976
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_208531
Cholesterol biosynthesis pathway
KEGG
mmu00100
Steroid biosynthesis pathway
mmu00140
Steroid hormone biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_9405
Cholesterol biosynthesis pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00140
Steroid hormone biosynthesis pathway
hsa00100
Steroid biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.12882 Mm.474133
RefSeq NM_010476
OMIM
CCDS CCDS35766
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca