Version 5.4
Mus musculus Protein: Gpd1l
Summary
InnateDB Protein IDBP-203720.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gpd1l
Protein Name glycerol-3-phosphate dehydrogenase 1-like
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000081913
InnateDB Gene IDBG-203718 (Gpd1l)
Protein Structure
UniProt Annotation
Function Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0017080 sodium channel regulator activity
GO:0042803 protein homodimerization activity
GO:0044325 ion channel binding
GO:0051287 NAD binding
Biological Process
GO:0002027 regulation of heart rate
GO:0005975 carbohydrate metabolic process
GO:0006072 glycerol-3-phosphate metabolic process
GO:0006734 NADH metabolic process
GO:0010765 positive regulation of sodium ion transport
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0046168 glycerol-3-phosphate catabolic process
GO:0055114 oxidation-reduction process
GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization
GO:0086005 ventricular cardiac muscle cell action potential
GO:0090038 negative regulation of protein kinase C signaling
GO:2000010 positive regulation of protein localization to cell surface
GO:2000649 regulation of sodium ion transmembrane transporter activity
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009331 glycerol-3-phosphate dehydrogenase complex
GO:0016020 membrane
Protein Structure and Domains
PDB ID MGI:1289257
InterPro IPR006109 Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal
IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent
IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like
IPR011128 Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal
IPR017751 Glycerol-3-phosphate dehydrogenase, NAD-dependent, eukaryotic
PFAM PF07479
PF01210
PRINTS PR00077
PIRSF PIRSF000114
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3ULJ0
PhosphoSite PhosphoSite-Q3ULJ0
TrEMBL
UniProt Splice Variant
Entrez Gene 333433
UniGene Mm.473019
RefSeq
MGI ID
MGI Symbol Gpd1l
OMIM
CCDS
HPRD
IMGT
EMBL AK050572 AK075845 AK145475 AK172886 BC037729
GenPept AAH37729 BAC34327 BAC36001 BAD32164 BAE26458

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca