InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Suz12

Summary

InnateDB Protein

IDBP-203785.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Suz12

Protein Name

suppressor of zeste 12 homolog (Drosophila)

Synonyms

2610028O16Rik; AI195385; AU016842; AW536442; D11Ertd530e; mKIAA0160;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000017692

InnateDB Gene

IDBG-203783 (Suz12)

Protein Structure

UniProt Annotation

Function

Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8. {ECO:0000250, ECO:0000269PubMed:15385962, ECO:0000269PubMed:15516932, ECO:0000269PubMed:17339329}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:16415857}. Chromosome {ECO:0000269PubMed:16415857}. Note=Localizes to the inactive X chromosome in trophoblast stem cells.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 79 interaction(s) predicted by orthology.

Experimentally validated
Total	49 [view]
Protein-Protein	40 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	79 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0035064	methylated histone binding
GO:0042054	histone methyltransferase activity
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0008284	positive regulation of cell proliferation
GO:0016571	histone methylation
GO:0016574	histone ubiquitination
GO:0045596	negative regulation of cell differentiation