InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hip1

Summary

InnateDB Protein

IDBP-203842.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hip1

Protein Name

huntingtin interacting protein 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000059033

InnateDB Gene

IDBG-203840 (Hip1)

Protein Structure

UniProt Annotation

Function

Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors. {ECO:0000250UniProtKB:O00291, ECO:0000269PubMed:11577110, ECO:0000269PubMed:11604514, ECO:0000269PubMed:12839988, ECO:0000269PubMed:14998932, ECO:0000269PubMed:16967501, ECO:0000269PubMed:17329427}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Endomembrane system {ECO:0000250}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250}. Note=Shuttles between cytoplasm and nucleus. Nuclear translocation can be induced by AR (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Most abundantly expressed in brain. In brain, expressed in cortical tissue, hippocampus, the molecular layer of the cerebellum and olfactory bulb. Also expressed in spinal cord and bone marrow (at protein level). Expressed in reproductive tissues. {ECO:0000269PubMed:11604514, ECO:0000269PubMed:12839988, ECO:0000269PubMed:14998932, ECO:0000269PubMed:16967501, ECO:0000269PubMed:9140394}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005488	binding
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0030276	clathrin binding
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006897	endocytosis
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0030154	cell differentiation
GO:0042981	regulation of apoptotic process
GO:0048260	positive regulation of receptor-mediated endocytosis
GO:0048268	clathrin coat assembly
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0030136	clathrin-coated vesicle
GO:0030665	clathrin-coated vesicle membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:1099804

InterPro

IPR001026 Epsin domain, N-terminal
IPR002558 I/LWEQ domain
IPR008942 ENTH/VHS
IPR011417 AP180 N-terminal homology (ANTH) domain
IPR013809 Epsin-like, N-terminal
IPR016024 Armadillo-type fold

PFAM

PF01417
PF01608
PF07651

PRINTS

PIRSF

SMART

SM00307
SM00273

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8VD75