Homo sapiens Protein: CHRNA6
Summary
InnateDB Protein IDBP-20387.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHRNA6
Protein Name cholinergic receptor, nicotinic, alpha 6
Synonyms CHNRA6;
Species Homo sapiens
Ensembl Protein ENSP00000276410
InnateDB Gene IDBG-20385 (CHRNA6)
Protein Structure
UniProt Annotation
Function After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular Localization Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004889 acetylcholine-activated cation-selective channel activity
GO:0005230 extracellular ligand-gated ion channel activity
GO:0005515 protein binding
GO:0015464 acetylcholine receptor activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006812 cation transport
GO:0007165 signal transduction
GO:0007268 synaptic transmission
GO:0014059 regulation of dopamine secretion
GO:0034220 ion transmembrane transport
GO:0051899 membrane depolarization
Cellular Component
GO:0005886 plasma membrane
GO:0005892 acetylcholine-gated channel complex
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID
InterPro IPR002394 Nicotinic acetylcholine receptor
IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding
PFAM PF02932
PF02931
PRINTS PR00254
PR00252
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q15825
PhosphoSite PhosphoSite-Q15825
TrEMBL E9PP97
UniProt Splice Variant
Entrez Gene 8973
UniGene Hs.730178
RefSeq NP_004189
HUGO HGNC:15963
OMIM 606888
CCDS CCDS6135
HPRD 06056
IMGT
EMBL AB079251 AC087533 AK298798 AK313521 BC014456 CH471080 U62435 Y16282
GenPept AAB40113 AAH14456 BAC06855 BAG36301 BAG60933 CAA76155 EAW63207