InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cops2

Summary

InnateDB Protein

IDBP-203872.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cops2

Protein Name

COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana)

Synonyms

AI315723; C85265; Csn2; Sgn2; TRIP-15; Trip15;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028635

InnateDB Gene

IDBG-203870 (Cops2)

Protein Structure

UniProt Annotation

Function

Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. {ECO:0000269PubMed:11967155, ECO:0000269PubMed:12522100, ECO:0000269PubMed:12972599}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10087198}. Nucleus {ECO:0000269PubMed:10087198}.

Disease Associations

Tissue Specificity

Widely expressed in embryonic, fetal and adult tissues, except cartilage and smooth muscle. {ECO:0000269PubMed:10087198}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 86 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	86 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0008283	cell proliferation
GO:0010388	cullin deneddylation
GO:0030182	neuron differentiation
GO:0035914	skeletal muscle cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated