Version 5.4
Mus musculus Protein: Nppa
Summary
InnateDB Protein IDBP-203993.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nppa
Protein Name natriuretic peptide type A
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000099520
InnateDB Gene IDBG-203991 (Nppa)
Protein Structure
UniProt Annotation
Function Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. {ECO:0000269PubMed:12890708, ECO:0000269PubMed:22437503, ECO:0000269PubMed:8760210}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005179 hormone activity
GO:0051428 peptide hormone receptor binding
Biological Process
GO:0001666 response to hypoxia
GO:0003085 negative regulation of systemic arterial blood pressure
GO:0006182 cGMP biosynthetic process
GO:0007168 receptor guanylyl cyclase signaling pathway
GO:0007565 female pregnancy
GO:0008217 regulation of blood pressure
GO:0014898 cardiac muscle hypertrophy in response to stress
GO:0030308 negative regulation of cell growth
GO:0032868 response to insulin
GO:0050880 regulation of blood vessel size
GO:0071260 cellular response to mechanical stimulus
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0042629 mast cell granule
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:97367
InterPro IPR000663 Natriuretic peptide
IPR002407 Natriuretic peptide, atrial type
IPR002408 Natriuretic peptide, brain type
PFAM PF00212
PRINTS PR00710
PR00711
PR00712
PIRSF
SMART SM00183
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P05125
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 230899
UniGene
RefSeq NP_032751
MGI ID
MGI Symbol Nppa
OMIM
CCDS CCDS18927
HPRD
IMGT
EMBL AK147180 AL714013 BC089615 CH466594 CU210867 K02781
GenPept AAA37235 AAH89615 BAE27742 CAM14483 CAQ52160 EDL14792

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca