InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nppa

Summary

InnateDB Gene

IDBG-203991.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nppa

Gene Name

natriuretic peptide type A

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000041616

Encoded Proteins

IDBP-203993

natriuretic peptide type A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175206:
The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:148000722-148002079

Strand

Forward strand

Band

Transcripts

ENSMUST00000103230

ENSMUSP00000099520

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005179	hormone activity
GO:0051428	peptide hormone receptor binding

Biological Process

GO:0001666	response to hypoxia
GO:0003085	negative regulation of systemic arterial blood pressure
GO:0006182	cGMP biosynthetic process
GO:0007168	receptor guanylyl cyclase signaling pathway
GO:0007565	female pregnancy
GO:0008217	regulation of blood pressure
GO:0014898	cardiac muscle hypertrophy in response to stress
GO:0030308	negative regulation of cell growth
GO:0032868	response to insulin
GO:0050880	regulation of blood vessel size
GO:0071260	cellular response to mechanical stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0042629	mast cell granule
GO:0048471	perinuclear region of cytoplasm