InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Clcn6

Summary

InnateDB Protein

IDBP-204013.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Clcn6

Protein Name

chloride channel 6

Synonyms

AI850629;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030879

InnateDB Gene

IDBG-204011 (Clcn6)

Protein Structure

UniProt Annotation

Function

Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter. {ECO:0000269PubMed:16950870}.

Subcellular Localization

Endosome membrane {ECO:0000269PubMed:16950870}; Multi-pass membrane protein {ECO:0000269PubMed:16950870}.

Disease Associations

Tissue Specificity

Detected in whole brain and in hippocampus neurons (at protein level). Detected in brain, trigeminus, dorsal root ganglion, spinal cord, eye, kidney, testis, skeletal muscle, thymus and pancreas. Isoform ClC-6c is expressed only in kidney. {ECO:0000269PubMed:16950870, ECO:0000269PubMed:9224655}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005247	voltage-gated chloride channel activity
GO:0005524	ATP binding
GO:0015297	antiporter activity
GO:0030554	adenyl nucleotide binding

Biological Process

GO:0006821	chloride transport
GO:0009612	response to mechanical stimulus
GO:0034220	ion transmembrane transport
GO:0044070	regulation of anion transport
GO:0055085	transmembrane transport