Version 5.4
Mus musculus Gene: Clcn6
Summary
InnateDB Gene IDBG-204011.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Clcn6
Gene Name chloride channel 6
Synonyms AI850629
Species Mus musculus
Ensembl Gene ENSMUSG00000029016
Encoded Proteins
IDBP-204013
chloride channel 6
IDBP-270300
chloride channel 6
IDBP-537554
chloride channel 6
IDBP-536456
chloride channel 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000011021:
This gene encodes a member of the voltage-dependent chloride channel protein family. Members of this family can function as either chloride channels or antiporters. This protein is primarily localized to late endosomes and functions as a chloride/proton antiporter. Alternate splicing results in both coding and non-coding variants. Additional alternately spliced variants have been described but their full-length structure is unknown. [provided by RefSeq, Mar 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:148004259-148038821
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000030879 ENSMUSP00000030879
ENSMUST00000105711 ENSMUSP00000101336
ENSMUST00000137724 ENSMUSP00000121751
ENSMUST00000134377
ENSMUST00000131232 ENSMUSP00000116153
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005247 voltage-gated chloride channel activity
GO:0005524 ATP binding
GO:0015297 antiporter activity
GO:0030554 adenyl nucleotide binding
Biological Process
GO:0006821 chloride transport
GO:0009612 response to mechanical stimulus
GO:0034220 ion transmembrane transport
GO:0044070 regulation of anion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005765 lysosomal membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000011021
View Gene Order
ENSBTAG00000020700
Not yet available
Pathways
NETPATH
REACTOME
REACT_196640
Stimuli-sensing channels pathway
REACT_262350
Ion channel transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D6RHT0
UniProt Splice Variant
Entrez Gene 26372
UniGene Mm.89987
RefSeq NM_011929
OMIM
CCDS CCDS18928
HPRD
IMGT
MGI ID MGI:1347049
MGI Symbol Clcn6
EMBL AL606929
GenPept
RNA Seq Atlas 26372

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca