InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rnf135

Summary

InnateDB Protein

IDBP-204023.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rnf135

Protein Name

ring finger protein 135

Synonyms

0610037N03Rik; 2410006N06Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000017839

InnateDB Gene

IDBG-204021 (Rnf135)

Protein Structure

UniProt Annotation

Function

Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses. Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta production (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0043021	ribonucleoprotein complex binding
GO:0046872	metal ion binding

Biological Process

GO:0016567	protein ubiquitination
GO:0032728	positive regulation of interferon-beta production
GO:0045087	innate immune response
GO:0045088	regulation of innate immune response

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:1919206

InterPro

IPR001841 Zinc finger, RING-type
IPR001870 B30.2/SPRY domain
IPR003877 SPla/RYanodine receptor SPRY
IPR003879 Butyrophylin-like
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR018355 SPla/RYanodine receptor subgroup
IPR018957 Zinc finger, C3HC4 RING-type

PFAM

PF13639
PF14634
PF00622
PF00097

PRINTS

PR01407

PIRSF

SMART

SM00184
SM00449

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt