InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc27a2

Summary

InnateDB Protein

IDBP-204077.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc27a2

Protein Name

solute carrier family 27 (fatty acid transporter), member 2

Synonyms

ACSVL1; FATP2; Vlac; Vlacs; VLCS;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000057595

InnateDB Gene

IDBG-204073 (Slc27a2)

Protein Structure

UniProt Annotation

Function

Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism (By similarity). May be involved in translocation of long-chain fatty acids (LFCA) across membranes. {ECO:0000250, ECO:0000269PubMed:15699031}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Peripheral membrane associated with the lumenal side of peroxisomes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Strong expression in liver and kidney, low expression in brain and testis, no expression in skeletal muscle and spleen. Shows uniform distribution in liver acinus. {ECO:0000269PubMed:11980911}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004467	long-chain fatty acid-CoA ligase activity
GO:0005102	receptor binding
GO:0005524	ATP binding
GO:0015245	fatty acid transporter activity
GO:0019899	enzyme binding
GO:0031957	very long-chain fatty acid-CoA ligase activity
GO:0050197	phytanate-CoA ligase activity
GO:0070251	pristanate-CoA ligase activity

Biological Process

GO:0000038	very long-chain fatty acid metabolic process
GO:0001561	fatty acid alpha-oxidation
GO:0001676	long-chain fatty acid metabolic process
GO:0006635	fatty acid beta-oxidation
GO:0006699	bile acid biosynthetic process
GO:0008152	metabolic process
GO:0015908	fatty acid transport
GO:0042760	very long-chain fatty acid catabolic process
GO:0044539	long-chain fatty acid import
GO:0097089	methyl-branched fatty acid metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0005779	integral component of peroxisomal membrane
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005789	endoplasmic reticulum membrane
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0070062	extracellular vesicular exosome